We should definitely be looking to rest against Wakey, both because we'll be coming off a tough game against Wigan and because we're on a 4-day turnaround to playing Cas, which they'll be hugely up for. If we win against Wigan we'll be 6 points clear of them so dropping points to Wakey is not such a problem, especially given the benefits of game time for those coming back from injuries and rest to key players.
After the Cas match we've got a 10-day turnaround before the pair of games against Hull, and then we've got back-to-back games against Saints and Wigan. Win those and we should be guaranteed to be in the four.